The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon–carbon bonds. It employs a palladium catalyst as well as copper co-catalyst to form a carbon–carbon bond between a terminal alkyne and an aryl or vinyl halide.

Sonogashira reaction examples catalyzed by cinchona alkaloid derivatives can be found in our free of charge Chiral Catalyst Search.

Example from literature

A general asymmetric copper-catalysed Sonogashira C (sp 3)–C (sp) coupling. (Liu et al.; Nat. Chem. 2019, 11(12), 1158-1166.)