A dearomatization reaction is an organic reaction which involves arenes as reactants and in which the reaction products have permanently lost their aromaticity. Dearomatization reactions provide rapid access to structurally complex three-dimensional molecules from simple aromatic compounds.

Please find further examples of Dearomatizations promoted by Cinchona Alkaloids in our Buchler Chiral Catalyst Search.

Example from literature

Organocatalytic Asymmetric One-Step Desymmetrizing Dearomatization Reaction of Indoles: Development and Bioactivity Evaluation. (Peng er al.; Angew. Chem. Int. Ed. 2019, 58, 216–220.)